The interdisciplinary research team at the Johns Hopkins Center for the Advancement of HIV Neurotherapeutics (JH CAHN) is dedicated to studying such conditions as HIV-associated central nervous system (CNS) disorders. We aim to translate discoveries of the pathophysiological mechanisms of these conditions into novel therapeutics, as well as provide educational and clinical resources to other HIV researchers across Johns Hopkins Medicine institutions and beyond. The JHDD serves as the Therapeutic Core at the center and is responsible for translating findings from basic and clinical research into novel therapeutics. Some of our ongoing collaborative projects that have therapeutic implications include Intranasal Insulin, Cystine/Glutamate Antiporter, Glutamine Antagonists, Glutaminase, and Neutral Sphingomyelinase 2.