2022 » Johns Hopkins Drug Discovery
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211. Galaj E, Bi GH, Klein B, Hempel B, Shaik AB, Gogarnoiu ES, Friedman J, Lam J, Rais R, Reed JF, Bloom SH, Swanson TL, Schmachtenberg JL, Eshleman AJ, Janowsky A, Xi ZX, Newman AH. “A highly D 3 R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D 3 R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder”, Neuropsychopharmacology, 2022. [Pubmed]

210. Pal A, Gori S, Yoo SW, Thomas AG, Wu Y, Friedman J, Tenora L, Bhasin H, Alt J, Haughey N, Slusher BS, Rais R. “Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP”, J Med Chem, 2022 [Pubmed]

209. Huang M, Xiong D, Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Montuenga LM, Wang Y, Slusher BS, You M. “Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer”, Adv Sci (Weinh), 2022. [Pubmed]

208. Bell BJ, Hollinger KR, Deme P, Sakamoto S, Hasegawa Y, Volsky D, Kamiya A, Haughey N, Zhu X, Slusher BS. “Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice”, Brain Behav Immun Health, 2022. [Pubmed]

207. Yang S, Datta D, Elizabeth Woo, Duque A, Morozov YM, Arellano J, Slusher BS, Wang M, Arnsten AFT. “Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders”, Mol Psychiatry, 2022. [Pubmed]

206. Krečmerová M, Majer P, Rais R, Slusher BS. “Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects”, Front Chem, 2022. [Pubmed]

205. Zhu X, Hollinger KR, Huang Y, Borjabad A, Kim BH, Arab T, Thomas AG, Moniruzzaman M, Lovell L, Turchinovich A, Witwer KW, Volsky DJ, Haughey NJ, Slusher BS. “Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV”, Neurobiol Dis, 2022. [Pubmed]

204. Wei H, Moffett JR, Amanat M, Fatemi A, Tsukamoto T, Namboodiri AM, Slusher BS. “The pathogenesis of, and pharmacological treatment for, Canavan disease”, Drug Discov Today, 2022 [Pubmed]

203. Parkhurst A, Wang SZ, Findlay TR, Malebranche KJ, Odabas A, Alt J, Maxwell MJ, Kaur H, Peer CJ, Figg WD, Warren KE, Slusher BS, Eberhart CG, Raabe EH, Rubens JA. “Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors”, Cell Death Dis, 13(4): 410, 2022. [Pubmed]

202. Lemberg KM, Gori SS, Tsukamoto T, Rais R, Slusher BS. “Clinical development of metabolic inhibitors for oncology”, J Clin Invest, 132(1), 2022. [Pubmed]

201. Tallon C, Sharma A, Zhang Z, Thomas AG, Ng J, Zhu X, Donoghue A, Schulte M, Joe TR, Kambhampati SP, Sharma R, Liaw K, Kannan S, Kannan RM, Slusher BS. “Dendrimer-2PMPA Delays Muscle Function Loss and Denervation in a Murine Model of Amyotrophic Lateral Sclerosis”, Neurotherapeutics, 19(1): 274-288, 2022. [Pubmed]

200. Hollinger KR, Sharma A, Tallon C, Lovell L, Thomas AG, Zhu X, Wiseman R, Wu Y, Kambhampati SP, Liaw K, Sharma R, Rojas C, Rais R, Kannan S, Kannan RM, Slusher BS. “Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis”, Nanotheranostics, 6(2): 126-142, 2022. [Pubmed]

199. Pham K, Hanaford AR, Poore BA, Maxwell MJ, Sweeney H, Parthasarathy A, Alt J, Rais R, Slusher BS, Eberhart CG, Raabe EH. “Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways”, Cancers (Basel), 14(5): 1311, 2022. [Pubmed]

198. Berhane I, Hin N, Thomas AG, Huang Q, Zhang C, Veeravalli V, Wu Y, Ng J, Alt J, Rojas C, Hihara H, Aoki M, Yoshizawa K, Nishioka T, Suzuki S, He SQ, Peng Q, Guan Y, Dong X, Raja SN, Slusher BS, Rais R, Tsukamoto T. “Thieno[2,3- d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1)”, J Med Chem, 65(4): 3218-3228, 2022. [Pubmed]

197. Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL. “High-throughput activity assay for screening inhibitors of the SARS-CoV-2 Mac1 Macrodomain”, ACS Chem Biol, 17(1): 17-23, 2022. [Pubmed]