2020 » Johns Hopkins Drug Discovery
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2020

178. Bell BJ, Malvankar MM, Tallon C, Slusher BS. “Sowing the seeds of discovery: tau-propagation models of Alzheimer’s disease”, ACS Chem Neurosci, 11(20):3499-3509, 2020 [Pubmed

177. Yamashita AS, da Costa Rosa M, Stumpo V, Rais R, Slusher BS, Riggins GJ. “The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling”, Neuro-oncology Adv2020. [N-O Adv]

176. Yoo SW, Agarwal A, Smith MD, Khuder SS, Baxi EG, Thomas AG, Rojas C, Moniruzzaman M, Slusher BS, Bergles DE, Calabresi PA, Haughey NJ. “Inhibition of neutral sphingomyelinase 2 promotes remyelination”, Sci Adv, 6(40):eaba5210, 2020. [Pubmed]

175. Ghosh A, Li L, Xu L, Dash RP, Gupta N, Lam J, Jin Q, Akshintala V, Pahapale G, Liu W, Sarkar A, Rais R, Gracias DH, Selaru FM. “Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo”, Sci Adv, 6(44):eabb4133, 2020. [Pubmed]

174. Sharma A, Liaw K, Sharma R, Thomas AG, Slusher BS, Kannan S, Kannan RM. “Targeting mitochondria in tumor-associated macrophages using a dendrimer-conjugated TSPO ligand that stimulates antitumor signaling in glioblastoma”, Biomacromolecules, 21(9):3909-3922, 2020 [Pubmed]

173. Li Z, Moniruzzaman M, Dastgheyb RM, Yoo SW, Wang M, Hao H, Liu J, Casaccia P, Nogueras-Ortiz C, Kapogiannis D, Slusher BS, Haughey NJ. “Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP”, J Extracellular Vesicles, 10(2):e12035, 2020. [Pubmed]

172. Giancola JB, Bonifazi A, Cao J, Ku T, Haraczy AJ, Lam J, Rais R, Coggiano MA, Tanda G, Newman AH. “Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability”, Eur J Med Chem, 208:112674, 2020. [Pubmed]

171. Duvall B, Zimmerman SC, Gao R, Thomas AG, Kalčic F, Veeravalli V, Elgogary A, Rais R, Rojas C, Le A, Slusher BS, Tsukamoto T. “Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker”, Bioorg Med Chem. 28(20):1115698, 2020. [Pubmed]

170. Ogura S, Baldeosingh R, Bhutto IA, Kambhampati S, McLeod DS, Edwards MM, Rais R, Schubert W, Lutty GA. “A role for mast cells in geographic atrophy”, FASEB J. 34(8):10117-10131, 2020. [Pubmed]

169. Lemberg KM, Wang J, Pratilas CA. “From genes to -omics: the evolving molecular landscape of malignant peripheral nerve sheath tumor”, Genes. 11(6):691, 2020. [Pubmed]

168. Hollinger KR, Zhu X, Khoury ES, Thomas AG, Liaw K, Tallon C, Wu Y, Prchalova E, Kamiya A, Kannan S, Slusher BS. “Glutamine antagonist JHU-083 normalizes aberrant hippocampal glutaminase activity and restores cognition in APOE4 mice”, J Alz Disease. 77(1):437-447, 2020. [Pubmed]

167. Khoury ES, Sharma A, Ramireddy RR, Thomas AG, Alt J, Fowler A, Rais R, Tsukamoto T, Blue ME, Slusher BS, Kannan S, Kannan RM. “Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a model of Rett syndrome”, Theranostics. 10(13): 5736-48, 2020. [Pubmed]

166. Nordengen K, Morland C, Slusher BS, Gunderson B. “Dendritic localization and Exocytosis of NAAG in the Rat Hippocampus”, Cerebral Cortex. 30(3):1422-1435, 2020. [PubMed

165. Deme P, Rojas C, Slusher BS, Rais R, Afghah Z, Geiger JD, Haughey NJ. “Bioenergetic Adaptations to HIV Infection. Could Modulation of Energy Substrate Utilization Improve Brain Health in People Living with HIV-1?”, Exp Neurol. 327:113181, 2020. [PubMed]

164. Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hrebabecky H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R. “Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Diesase”, J Med Chem. 63(11):6028-6056, 2020. [PubMed]

163. Oh M, Sun I, Zhao L, Leone RD, Sun I, Xu W, Collins SL, Tam AJ, Blosser RL, Patel CH, Englert JM, Arwood ML, Wen J, Chan-Li Y, Tenora L, Majer P, Rais R, Slusher BS, Horton MR, Powell JD. “Targeting Glutamine Metabolism Enhances Tumor Specific Immunity by Modulating Suppressive Myeloid Cells”, J Clin Invest. 130(7):3865-3884, 2020. [PubMed]

162. Lemberg KM, Zhao L, Wu Y, Veeravalli V, Alt J, Aguilar JMH, Dash RP, Lam J, Tenora L, Rodriguez C, Nedelcovych MT, Brayton C, Majer P, Blakeley JO, Rais R, Slusher BS.  “The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor.”  Mol Cancer Ther, 19(2): 397-408, 2020. [PubMed]

 

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