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News & Events

December 2017

August 2017

Cruising on the boat
Hanging out on the boat
Rana and Usman fishing
Everybody together!
Caught a fish!

July 2017

The summer bash!

June 2017

  • Johns Hopkins Drug Discovery presents 6 posters at the First Annual Bloomberg~Kimmel Institute for Cancer Immunotherapy Scientific Retreat

  • Ajit Thomas presented new insight on the molecular mechanism of action of Netupitant/Palonosetron (NEPA) for the treatment of chemotherapy-induced nausea and vomiting at the MASCC 2017 meeting in Washington, D.C. Click here for more information

JHDD scientists presented their latest findings on NEPA mechanism of action during the MASCC meeting in Washington on June 23. NEPA is a drug combination of netupitant and palonosetron used for the treatment of chemotherapy-induced nausea and vomiting (CINV). Previous work has shown that both palonosetron and netupitant can induce 5-HT3 and NK1 receptor internalization and that this could help explain the long-term action of this agent in CINV prevention. One question that has often been asked is what happens to the receptors after they are internalized. The latest work using HEK 293 cells that express the NK1 receptor shows that when using the NK1 receptor antagonist netupitant by itself or in combination with palonosetron (NEPA), NK1 receptors were internalized and remained internalized 6h after exposure to the antagonist. In contrast, the NK1 receptor could be internalized by its agonist, substance P (SP), and subsequently recycled to the cell surface within 4h of SP exposure. The results indicate that the antagonists trigger internalization without recycling and suggest receptors may undergo degradation. Read more

December 2016

  • Novel Prodrugs of 6-Diazo-5-Oxo-L-Norleucine With More Brain Delivery
  • Rana Rais and Jonathan Powell present “Design of cell-targeted glutamine antagonists for cancer treatment” at the Johns Hopkins ICTR and CFAR Second Annual Symposium

  • Mike Nedelcovych presents Johns Hopkins Clinical Pharmacology Lecture on “Glutamine Antagonism as a Cognition Enhancing Therapeutic in EcoHIV mice”

  • Johns Hopkins Drug Discovery hosts its annual Holiday Luncheon and Santa Swap Party at Woodberry Kitchen Click here to see photos

Holiday Luncheon at Woodberry Kitchen

November 2016

  • Johns Hopkins Drug Discovery goes bowling at Mustang Alley’s: green team wins again 🙂  Click here to see photos

Jesse, Eva, Angie, Bridget and Pavel
Mark, Camilo, Krystyna, Alex and Rana
Arena, Niyada, Barb, Mike and Ondrej
Matt, Takashi, Kristin, Georg and Mohamed
Mark, Rana and Alex

August 2016

July 2016

The group on the dock while fishing

June 2016

  • Johns Hopkins Drug Discovery Receives Sanofi iAWARD for new Inflammatory Bowel Disease (IBD) therapeutics

  • Johns Hopkins Drug Discovery hosts high school summer science camp Click here to see photos