2021 » Johns Hopkins Drug Discovery
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2021

196. Nizawa T, Bhutto IA, Tiwari A, Grebe R, Alt J, Rais R, Edwards MM, Lutty GA. “Topical ketotifen fumarate inhibits choroidal mast cell degranulation and loss of retinal pigment epithelial cells in rat models for geographic atrophy”, Transl Vis Sci Technol, 10(14):37, 2021 [Pubmed]

195. Fu X, Shah AP, Keighron J, Mou TM, Ladenheim B, Alt J, Fukudome D, Niwa M, Tamashiro KL, Tanda G, Sawa A, Cadet J, Rais R, Baraban JM. “Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity”, Transl Psych, 11(1): 427, 2021 [Pubmed]

194. Nesuta O, Thomas AG, Alt J, Hin N, Neuzilova A, Long S, Tsukamoto T, Rojas C, Wei H, Slusher BS. “High throughput screening cascade to identify human Aspartate N-Acetyltransferase (ANAT) inhibitors for Canavan disease”, ACS Chem Neurosci, 12(18):3445-3455, 2021 [Pubmed]

193. Datta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. “Glutamate carboxypeptidase II in aging rat prefrontal cortex impairs working memory performance”, Front Aging Neurosci, 2021 [Pubmed]

192. Tallon C, Picciolini S, Yoo SW, Thomas AG, Pal A, Alt J, Carlomagno C, Gualerzi A, Rais R, Haughey NJ, Bedoni M, Slusher BS. “Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury”, Biochem Pharmacol, 2021 [Pubmed]

191. Alt J, Gori SS, Lemberg KM, Pal A, Veeravalli V, Wu Y, Aguilar JMH, Dash RP, Tenora L, Majer P, Sun Q, Slusher BS, Rais R. “Glutamine antagonist GA-607 causes a dramatic accumulation of FGAR which can be used to monitor target engagement”, Curr Drug Metab, 2021 [Pubmed]

190. Gao RD, Hin N, Prchalová E, Pal A, Lam J, Rais R, Slusher BS, Tsukamoto T. “Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-L-norleucine containing a diazo precursor”, Bioorg Med Chem Letters, 2021 [Pubmed]

189. Cetinkaya-Fisgin A, Zhu J, Luan X, Kim JS, Oh B, Brayton C, Alt J, Rais R, Slusher B, Höke A. “Development of EQ-6, a novel analogue of ethoxyquin to prevent chemotherapy-induced peripheral neuropathy”, Neurotherapeutics, 2021 [Pubmed]

188. Akeus P, Szeponik L, Langenes V, Karlsson V, Sundström P, Bexe-Lindskog E, Tallon C, Slusher BS, Quiding-Järbrink M. “Regulatory T cells reduce endothelial neutral sphingomyelinase 2 to prevent T-cell migration into tumors”, Eur J Immunol, 2021 [Pubmed]

187. Arab T, Mallick ER, Huang Y, Dong L, Liao Z, Zhao Z, Gololobova O, Smith B, Haughey NJ, Pienta KJ, Slusher BS, Tarwater PM, Tosar JP, Zivkovic AM, Vreeland WN, Paulaitis ME, Witwer KW. “Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single-particle analysis platforms”, J Extracell Vesicles, 10(6):e12079, 2021 [Pubmed]

186. Tallon C, Hollinger KR, Pal A, Bell BJ, Rais R, Tsukamoto T, Witwer KW, Haughey NJ, Slusher BS. “Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases”, Drug Discov Today, 26(7):1656-1668, 2021 [Pubmed]

185. Pham K, Maxwell MJ, Sweeney H, Alt J, Rais R, Eberhart CG, Slusher BS, Raabe EH. “Novel glutamine antagonist JHU-395 suppresses MYC-driven medulloblastoma growth and induces apoptosis”, J Neuropathol Exp Neurol, 80(4):336-344, 2021 [Pubmed]

184. Maynard RE, Poore B, Hanaford AR, Pham K, James M, Alt J, Park Y, Slusher BS, Tamayo P, Mesirov J, Archer TC, Pomeroy SL, Eberhart CG, Raabe EH. “TORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of C-MYC medulloblastoma”, Cancer Letters, 504:137-145, 2021 [Pubmed

183. Su Y, DePasquale M, Liao G, Buchler I, Zhang G, Byers S, Carr GV, Barrow J, Wei J. “Membrane bound catechol-O-methyltransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain”, Eur J Pharmacol, 2021 [Pubmed

182. Hossain MI, Thomas AG, Mahdi F, Adam AT, Akins NS, Woodard MM, Paris JJ, Slusher BS, Le HV. “An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity”, RSC Adv, 11(13): 7115-7128, 2021 [Pubmed]

181. Artega Cabeza O, Zhang Z, Khoury ES, Sheldon RA, Sharma A, Zhang F, Slusher BS, Kannan RM, Kannan S, Ferriero DM. “Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury”, Neurobiol Dis, 148:105201, 2021 [Pubmed

180. Harraz MM, Guha P, Kang IG, Semenza ER, Malla AP, Song YJ, Reilly L, Treisman I, Cortés P, Coggiano MA, Veeravalli V, Rais R, Tanda G, Snyder S. “Cocaine-induced locomotor stimulation involves autophagic degradation of the dopamine transporter”, Mol Psych, 26(2):370-382, 2021 [Pubmed

179. Skácel J, Slusher BS, Tsukamoto T. “Small molecule inhibitors targeting biosynthesis of ceramide, the central hub of the sphingolipid network”, J Med Chem, 64(1):279-297, 2021 [Pubmed

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