Johns Hopkins Drug Discovery - Courses - Introduction to Drug Discovery Research
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Introduction to Drug Discovery Research (ME:200.704)

This course deals with various aspects of the drug discovery process including target identification, medicinal chemistry, in vitro and in vivo drug screening methods, pharmacokinetics, drug safety, intellectual property, and biologics. The last two lectures are devoted to case studies in which discovery of particular drugs will be discussed in detail to provide further insights into the process of drug discovery research.  Each lecture is given by an expert on the given subject with many years of translational research experience.  Students will build a broad knowledge base that will allow them to prepare for a career in pharmaceutical research or basic medical science with implications for novel therapeutics.

Introduction to Drug Discovery Research (ME:200.704)

Spring 2018

Course Director: Takashi Tsukamoto (ttsukamoto@jhmi.edu)

Location: Rangos Building Room 590

Time: 10:00 AM – 11:30 AM

Dates: Every Friday 1/12/2018-4/27/2018

Blackboard will be used to communicate with students, share course materials, make announcements, and post grades.  Grades will be determined by quiz participation (given at the end of each lecture, 1/3), Mid-term Exam (1/3), and Final Exam (1/3).  No quiz will be given at the first lecture.

Prerequisite: No prior knowledge in drug discovery is required.  This course is recommended for students in the 2nd or subsequent years of their graduate program.  Please contact Dr. Takashi Tsukamoto (ttsukamoto@jhmi.edu) for more information.


Topic Lecturer
1/12 Introduction Takashi Tsukamoto
1/19 Drug-like properties and druggable targets Takashi Tsukamoto
1/26 in vitro Pharmacology I Camilo Rojas
2/2 in vitro Pharmacology II Camilo Rojas
2/9 in vitro Pharmacokinetics Rana Rais
2/16 in vivo Pharmacokinetics Takashi Tsukamoto
2/23 Drug Safety Adaline Smith
3/2 Midterm Exam
3/9 Spring Break
3/16 in vivo Pharmacology  Krystyna Wozniak
3/23 Intellectual Property  Jeff Childers
3/30 Lead Optimization  Takashi Tsukamoto
 4/6  Biologics Roland Kolbeck
 4/13  Case Study I (Sitagliptin)  Jim Barrow
 4/20  Case Study II (Imatinib) David Meyers
 4/27   Final Exam

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