2018 » Johns Hopkins Drug Discovery
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2018

128. Zimmermann SC, Duvall B, Tsukamoto T. “Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase” J Med Chem. 2018 Jul 3. [Epub ahead of print]

 

127. Zhu X., Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. “JHU-083 selectively blocks glutaminase activity in brain CD11b+cells and prevents depression-associated behaviors induced by chronic social defeat stress.” Neuropsychopharmacology. 2018 Aug 13. PMID 30127344 [Epub ahead of print]

 

126. Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F. “NaV1.1 inhibition can reduce visceral hypersensitivity.” JCI Insight. 2018 Jun 7;3(11). PMID 29875317 [Epub ahead of print]

 

125. Liraz-Zaltsman S, Slusher BS, Atrakchi-Baranes D, Rosenblatt K, Friedman Levi Y, Kesner EL, Silva AJ, Biegon A, Shohami E. “Enhancement of brain D-serine mediates recovery of cognitive function after TBI.” J Neurotrauma. 2018 Mar 14, PMID 29648983 [PubMed]

 

124. Zimmermann SC, Tichy T, Vavra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jancarik A, Tenora L, Monincova L, Prchalova E, Riggins GJ, Majer P, Slusher BS, Rais R. “N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.” J Med Chem. 2018 Apr 19, PMID 29648826 [PubMed]

 

123.  Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF.  “Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.” Neuropharmacology, 2018, Mar 15, 131:96-103. [PubMed]

 

122.  Wozniak KM, Vornov JJ, Wu Y, Liu Y, Carozzi VA, Rodriguez-Menendez V, Ballarini E, Alberti P, Pozzi E, Semperboni S, Cook BM, Littlefield BA, Nomoto K, Condon K, Eckley S, DesJardins C, Wilson L, Jordan MA, Feinstein SC, Cavaletti G, Polydefkis M, Slusher BS. “Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery.”  Cancer Res. 2018, Feb 1;78(3):817-829 [PubMed]

 

121.  Soomro I, Sun Y, Li Z, Diggs L, Hatzivassiliou G, Thomas AG, Rais R, Slusher BS, Somlo S, Skolnik EY.  “Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.”  Nephrol Dial Transplant. 2018 Feb 5 PMID:29420817  [Epub ahead of print]

 

120.  Nedelcovych MT, Gadiano AJ, Wu Y, Manning AA, Thomas AG, Khuder SS, Yoo SW, Xu J, McArthur JC, Haughey NJ, Volsky DJ, Rais R, Slusher BS. “Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.” ACS Chem Neurosci. 2018 Apr 18;9(4):809-816 PMID: 29257872 [PubMed]

 

119.  Rojas C, Stathis M, Coughlin JM, Pomper M, Slusher BS.  “The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.”  J Neuroimmune Pharmacol. 2018 Mar;13(1):1-5 PMID:28875261 [PubMed]

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