2016 » Johns Hopkins Drug Discovery
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2016

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102. Rais R, Jancarik A, Tenora L, Nedelcovych M, Alt J, Englert J, Rojas C, Le A, Elgogary A, Tan J, Monincova L, Pate K, Adam RJ, Ferraris DV, Powell JD, Majer P, Slusher BS.  “Discovery of 6-Diazo-5-oxo-L-norleucine (DON) prodrugs with enhanced CSF delivery in monkeys: a potential treatment for glioblastoma.”  Journal of Medicinal Chemistry, 2016, Sep 22;59(18):8621-33.  [PubMed]

 

101. Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, Hartung T, Rojas C, Rais R, Tsukamoto T, Semenza GL, Hanes J, Slusher BS, Le A.  “Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.”  Proceedings of the National Academy of Sciences, 2016, Sep 6;113(36):E5328-36. [PubMed]

 

100. Personius KE, Slusher BS, Udin SB. “Neuromuscular NMDA receptors modulate developmental synapse elimination.” Journal of Neuroscience, 2016, 36(34): 8783-8789. [PubMed]

 

99.  Smith J, Slusher BS, Wozniak KM, Farah MH, Smiyun G, Wilson L, Feinstein S, Jordan MA.  “Structural basis for induction of peripheral neuropathy by microtubule-targeting cancer drugs.” Cancer Research, 2016, 76 (17), 5115-5123. [PubMed]

 

98.  Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, and Newman AH. “Highly selective dopamine D3 receptor (D3R) antagonists and partial agonists based on eticlopride and the D3R crystal structure: new leads for opioid for dependence treatment.” Journal of Medicinal Chemistry, 2016, Aug 25;59(16):7634-50. [PubMed]

 

97.  Manivannan S, Baxter VK, Schultz KL, Slusher BS, Griffin DE. “Protective effects of glutamine antagonist DON in mice with alphaviral encephalomyelitis.” Journal of Virology, 2016, Sept 29;90(20):9251-62.  [PubMed]

 

96. Rais R, Jiang W, Zhai H, Wozniak KM, Stathis M, Hollinger KR, Thomas AG, Rojas C, Vornov JJ, Marohn M, Li X, Slusher BS. “FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities.” JCI Insight, 2016, Aug 4;1(12). [PubMed]

 

95. Barbour PM, Wang W, Chang L, Pickard KL, Rais R, Slusher BS, Wang X. “Property-guided synthesis of Aza-Tricyclic Indolines: Development of gold catalysis en route.”  Adv Synthesis & Catalysis, 2016, 358, 1482-1490.

 

94. Akutagawa J, Huang TQ, Epstein I, Chang T, Quirindongo-Crespo M, Cottonham CL, Dail M, Slusher BS, Friedman LS, Sampath D, Braun BS. “Targeting the P13K/Akt pathway in murine MDS/MPN driven by hyperactive Ras.” Leukemia, 2016, Jun;30(6):1335-43. [PubMed]

 

93. Vornov JJ, Hollinger KR, Jackson PF, Wozniak KM, Farah MH, Majer P, Rais R, Slusher BS. “Still NAAG’ing after all these years: The continuing pursuit of GCPII inhibitors.” Adv Pharmacol.  2016, 76:215-55.  [PubMed]

 

92. Tasnim A, Rammelkamp Z, Slusher AB, Wozniak K, Slusher BS, Farah MH. “Paclitaxel causes degeneration of both central and peripheral axon branches of dorsal root ganglia in mice.” BMC Neurosci. 2016, Jul 11:17(1):47. [PubMed]

 

91. Conway RE, Rojas C, Alt J, Novakova Z, Richarson SM, Rodrick TC, Fuentes JL, Richardson NH, Attalla J, Stewart S, Fahmy B, Barinka C, Ghosh M, Shapiro LH, Slusher BS. “Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide.” Angiogensis. 2016, Oct;19(4):487-500. [PubMed]

 

90. Zhang Z, Bassam B, Thomas AG, Williams M, Liu J, Nance E, Rojas C, Slusher BS, Kannan S. “Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain.”  Neurobiol Dis. 2016, Oct 31;94:116-28. [PubMed]

 

89. Rojas C, Alt J, Ator NA, Wilmoth H, Rais R, Hin N, DeVivo M, Popiolek M, Tsukamoto T, Slusher BS.  “Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect.” J Psychopharmacol, 2016, Sep;30(9):887-95. [PubMed]

 

88. Zimmermann SC, Wolf EF, Luu A, Thomas AG, Stathis M, Poore B, Nguyen C, Le A, Rojas C, Slusher BS.  “Allosteric glutaminase inhibitors based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane scaffold.” ACS Med Chem Lett, 2016, Mar 13;7(5):520-4. [PubMed]

 

87. Wozniak KM, Vornov JJ, Wu Y, Nomoto K, Littlefield BA, DesJardins C, Yu Y, Lai G, Reyderman L, Wong N, Slusher BS.  “Sustained accumulation of microtubule-binding chemotherapy drugs in the peripheral nervous system.” Cancer Research, 2016, Jun 1;76(11):3332-9. [PubMed]

 

86. Novakova Z, Wozniak K, Jancarik A, Rais R, Wu Y, Pavlicek J, Ferraris DV, Havlinova B, Ptacek J, Vavra J, Hin N, Rojas C, Majer P, Slusher BS, Tsukamoto T, Barinka C.  “Unprecedented binding mode of hydroxamate-based inhibitors of glutamate carboxypeptidase II: structural characterization and biological activity.” J Med Chem, 2016, May 26;59(10):4539-50. [PubMed]

 

85.  Rojas C, Alt J, Ator NA, Thomas AG, Wu Y, Hin N, Wozniak K, Ferraris D, Rais R, Tsukamoto T, Slusher BS.  “D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.” Neuropsychopharmacology, 2016, May;41(6):1610-9.  [PubMed]

 

84. Hin N, Duvall B, Berry JF, Ferraris DV, Rais R, Alt J, Rojas C, Slusher BS, Tsukamoto T. “D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.” Bioorg Med Chem Lett. 2016, Apr 15;26(8):2088-91. [PubMed]

 

83. Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher BS, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. “HIV-associated neurocognitive disorder – pathogenesis and prospects for treatment.” Nat Rev Neurol. 2016, Apr;12(4):234-48. [PubMed]

 

82. Majer P, Jancarik A, Krecmerova M, Tichy T, Tenora L, Wozniak K, Wu, Y, Pommier E, Ferraris D, Rais R, Slusher BS. “Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA).” J Med Chem, 2016, Mar. 24;59(6):2810-9. [PubMed]

 

81. Hollinger KR, Alt J, Riehm AM, Slusher Bs, Kaplin AI.  “Dose-dependent inhibition of GCPII to prevent and treat cognitive impairment in the EAE model of multiple sclerosis.” Brain Research, 2016, Mar 15;1635: 105-112.  [PubMed]

 

80. Benbow SJ, Cook BM, Reifert J, Wozniak KM, Slusher BS, Littlefield BA, Wilson L, Jordan MA, Feinstein SC. “Effects of Paclitaxel and Eribulin in Mouse Sciatic Nerve: A Microtubule-Based Rationale for the Differential Induction of Chemotherapy-Induced Peripheral Neuropathy.” Neurotoxicity Research, 2016, Feb; 29(2):299-313, 1-15.  [PubMed]